Age-related diseases account for over 50 percent of the global disease burden. A report from Healthspan Capital highlights key players, trends, and technologies that target the root causes of aging. Which longevity biotech companies are leading the way in 2025 to extend healthy human lifespan?
The longevity biotech field is at an inflection point where its acceptance by society and policymakers will determine how quickly it develops. The interest is growing—but more is needed. The field has accelerated rapidly over the past two decades due to scientific advancements in aging research, including genetic manipulation and AI-driven biology.
Healthspan Capital is a venture capital firm investing in longevity biotechnology (“LongBio”) and regenerative medicine. In their new report, LongBio Report 2025, they highlight that people are living longer, but in poor health, and that the aging process itself drives most disease and decline. Therefore, by targeting aging, we can prevent and treat most ailments. The authors—Alexander Tchernev, Nathan Cheng, Sebastian Brunemeier, and Michael Chinen—write:
“Our health is our most valuable asset. Let’s invest in it.”
And they leave us with this thought:
“Imagine a future where each passing birthday no longer reminds us of the limited time we have left, but rather serves as a countdown toward the incredible future we can look forward to exploring—and building.”
The report highlights six different areas and has identified leading LongBio companies within each area working to prevent, treat, and reverse aging.
6 Areas with Potential to Extend Healthy Human Lifespan
Removal
To eliminate or reverse detrimental changes that occur during aging. Examples include the elimination of senescent cells or the reversal of harmful chemical modifications.
Replacement
To replace components that become dysfunctional with age, such as mitochondria, stem cells, and organs.
Reprogramming
To rejuvenate cells using reprogramming factors (such as the Yamanaka factors) without erasing cellular identity.
Discovery Platforms
Platforms to identify interventions that affect the aging process without having a specific molecular target in mind from the outset.
Metabolic Modulation
Manipulation of metabolic pathways, for example inhibiting mTOR and NNMT, activating AMPK and the apelin receptor, reducing inflammaging, and using stem cell secretions.
Multiple Mechanisms
Simultaneously pursuing multiple mechanisms of action (MoAs) to target the aging process.
46 Leading Longevity Biotech Companies – The Full List
The report identifies companies in these areas with the potential for their technology to significantly increase human healthspan and lifespan.
Removal
- Arda Therapeutics: Taking aim at chronic diseases by depleting the pathogenic cells that drive them.
- Cyclarity Therapeutics: Removing arterial plaque by clearing the non-degradable cholesterol that accumulates within cells in the arterial walls.
- Deciduous Therapeutics: Positively impacting human healthspan by developing novel medicines that activate the endogenous immune mechanism responsible for the elimination of senescent cells.
- Metanoia Bio: Promoting functional cellular regeneration and reversing age-related chronic diseases.
- Oisin Biotechnologies: Developing genetic medicines delivered via proteo-lipid vehicles (PLVs) to make people live healthier and longer.
- Repair Biotechnologies: Regressing atherosclerotic plaque to eliminate cardiovascular mortality.
- Revel Pharmaceuticals: Developing enzymes to reverse the molecular damage that accumulates during aging.
- Rubedo Life Sciences: Eliminating pathologic cells – including senescent cells – that drive teh aging process and create disease.
Replacement
- Cellvie: Pioneering therapeutic mitochondria transplantation to boost cellular energy metabolism and deliver gene therapies.
- ImmuneAge Bio: Developing a drug discovery platform for immune system rejuvenation.
- LyGenesis: Transforming a patient’s lymph nodes into bioreactors capable of growing functioning ectopic organs.
- Minovia Therapeutics: Enriching the hematopoietic and progenitor cells of patients with functional mitochondria isolated from a healthy donor.
- Renewal Bio: Developing human stem cell-derived embryo models for replacement theraphy.
- Thymmune Therapeutics: Restoring immune function through thymic cell engineering.
- Vita Therapeutics: Utilizing iPSCs to engineer specific cell types that can replace those that are defective in patients.
Reprogramming
- Altos Labs: Restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.
- NewLimit: Epigenetically reprogramming cells to younger states.
- Shift Bioscience: Discovering a gene combination for safe rejuvenation of multiple cell types, ultimately delivering an approved drug for age-linked diseases.
- Turn Biotechnologies: Developing epigenetic reprogramming medicines and technology to maintain quiescent stem cell function.
Discovery Platforms
- BioAge Labs: harnessing the biology of human aging to develop new therapies for metabolic diseases.
- Gero: Deploying physics-informed AI/ML methods to solve age-related diseases and aging.
- Gordian Biotechnology: Developing gene therapies for complex aging-related diseases using a unique three-pillar in vivo platform.
- Rejuvenate Biomed: Finding combinations of existing drugs that delay the onset of aging-related diseases by influencing the aging process.
Metabolic Modulation
- Aeovian Pharmaceuticals: Developing small molecule inhibitors of mTTORC1 and CD38 for the treatment of genetic and aging-related diseases.
- Alkahest: Understanding and harnessing the plasma proteome to develop therapies for aging-related diseases.
- Amplifier Therapeutics: harnessing the broad therapeutic applications of AMPK activation.
- Epirium Bio: Developing a novel class of oral small molecules to improve muscle function and regeneration.
- Etheros Pharmaceuticals: Preventing neurodegeneration and extending healthspan with drugs that mimic endogenous neuroprotective enzymes.
- Immunis Biomedical: Improving quality of life using novel stem cell-derived secretome therapies to treat age-driven diseases.
- Juvena Therapeutics: Pioneering therapies tor myopathies and metabolic diseases.
- Rejuvenation Technologies: Pioneering therapeutic telomere extension by delivering modified mRNA encoding the telomerase enzyme.
- Remedium Bio: Bringing the curative potential of gene therapy to prevalent diseases.
- Reservoir Neuroscience: Rejuvenating the aging brain by restoring health to the brain’s blood vessels.
- Ridgeline Therapeutics: Developing potent small molecule inhibitors of nicotinamide N-methyltransferase to treat chronic and age-related diseases.
- Samsara Therapeutics: Treating age-related neurodegenerative diseases by improving autophagy.
- Telos Biotech: Creating technology to maintain telomere length during cell theraphy manufacturing.
- Tornado Therapeutics: Treating and preventing diseases by targeting mTOR.
- Vincere Biosciences: Advancing mitophagy-enhancing medicines to target age-related diseases such as Parkinson’s and kidney disease.
- Zoe Biosciences: Developing breakthrough API-1 inhibitors and apelin receptor agonists to extend human healthspan.
Multiple Mechanisms
- Calico Labs: Working to better understand the biology of aging to discover and develop interventions that enable people to live longer and healthier lives.
- Cambrian Biopharma: Developing medicines to target the mechanistic drivers of aging – first as treatments and then as preventive medicines.
- Centenara Labs: Developing and investing in therapies that target the hallmarks of aging to extend healthspan and lifespan.
- Juvenescence_ Developing and investing in medicines that target core aging mechanisms to prevent and treat age-related diseases.
- Life Biosciences: Developing therapies to partial epigenetic reprogramming and enhancement of chaperone-mediated autophagy.
- Matter Bioworks: Increasing genomic stability to unlock healthy longevity.
- Retro Biosciences: Pursuing multiple therapeutic avenues simultaneously to slow and reverse the aging process.
Read the full report
If you want to dive deeper, read more and download the full LongBio report 2025 here.
