Did you know that your body produces a protein called Klotho, which researchers believe can influence how long we live and how healthy we stay as we age? Named after one of the Greek Fates who spins the thread of life, Klotho plays a crucial role in slowing down aging processes in the body.
What is Klotho?
Klotho is a protein naturally produced in the kidneys and certain other tissues. It acts as an anti-aging molecule by regulating cellular functions, inflammation, and oxidative stress. Research shows that Klotho protects against cell damage and tissue aging by reducing harmful reactive oxygen species, also known as oxidative stress (Kuro-o et al., 1997). Additionally, Klotho is essential for maintaining calcium and phosphorus balance in the body, which is critical for healthy bones and preventing vascular calcification (Erben, 2018).
The Link to Longevity
Studies in mice have shown that those lacking the Klotho gene exhibit signs of premature aging, such as osteoporosis, vascular calcification, and kidney failure. In contrast, mice genetically modified to produce more Klotho live up to 30% longer than normal (Kurosu et al., 2005).
In humans, higher levels of the Klotho protein have been associated with better cognitive performance. For instance, a study found that individuals with genetic variations increasing Klotho levels perform better on working memory and problem-solving tests (Dubal et al., 2014). Researchers have also identified that Klotho may protect against cardiovascular diseases by reducing inflammation and oxidative stress in blood vessels (Semba et al., 2014).
The Future of Medicine?
In recent years, interest in Klotho as a potential therapeutic target has surged. Researchers are exploring whether Klotho injections or drugs that boost its levels in the body could slow aging and treat age-related diseases. In experiments, Klotho treatments have been shown to improve kidney function and reduce vascular calcification in animal models (Hu et al., 2017).
Although we are still in the early stages of fully understanding Klotho, it is considered a promising piece of the longevity puzzle – the science of extending our healthy lifespan.
Klotho is yet another example of how modern biology can help us understand and potentially influence aging. Perhaps the future is closer than we think, where we can use the body’s own systems to stay healthier and younger for longer.
